Transformative impact of proteomics on cardiovascular health and disease: a scientific statement from the American Heart Association

ML Lindsey, M Mayr, AV Gomes, C Delles, DK Arrell… - Circulation, 2015 - Am Heart Assoc
The year 2014 marked the 20th anniversary of the coining of the term proteomics. The
purpose of this scientific statement is to summarize advances over this period that have …

Effects of hypertension and exercise on cardiac proteome remodelling

BA Petriz, OL Franco - BioMed research international, 2014 - Wiley Online Library
Left ventricle hypertrophy is a common outcome of pressure overload stimulus closely
associated with hypertension. This process is triggered by adverse molecular signalling …

Cathepsin‐L Ameliorates Cardiac Hypertrophy Through Activation of the Autophagy–Lysosomal Dependent Protein Processing Pathways

M Sun, M Ouzounian, G de Couto, M Chen… - Journal of the …, 2013 - Am Heart Assoc
Background Autophagy is critical in the maintenance of cellular protein quality control, the
final step of which involves the fusion of autophagosomes with lysosomes. Cathepsin‐L …

Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning

AP Wojtovich, WR Urciuoli… - American Journal …, 2013 - journals.physiology.org
ATP-sensitive K+ (KATP) channels that contain K+ inward rectifier subunits of the 6.2 isotype
(Kir6. 2) are important regulators of the cardiac response to ischemia-reperfusion (I/R) injury …

A pilot study of angiogenin in heart failure with preserved ejection fraction: a novel potential biomarker for diagnosis and prognosis?

H Jiang, L Zhang, Y Yu, M Liu, X Jin… - Journal of Cellular …, 2014 - Wiley Online Library
Characteristics of heart failure with preserved ejection fraction (HFPEF) have not yet been
fully understood. The objectives of this pilot study are to detect protein expression profile in …

A supervised learning based decision support system for multi-sensor healthcare data from wireless body sensor networks

JJ Jijesh, Shivashankar, Keshavamurthy - Wireless Personal …, 2021 - Springer
Wireless body sensor network (WBSN) is also known as wearable sensors with transmission
capabilities, computation, storage and sensing. In this paper, a supervised learning based …

Kir6.2 limits Ca2+ overload and mitochondrial oscillations of ventricular myocytes in response to metabolic stress

NM Storey, RC Stratton, RD Rainbow… - American Journal …, 2013 - journals.physiology.org
ATP-sensitive K+ (KATP) channels are abundant membrane proteins in cardiac myocytes
that are directly gated by intracellular ATP and form a signaling complex with metabolic …

[HTML][HTML] Omics-based clinical discovery: Science, technology, and applications

CM Micheel, SJ Nass, GS Omenn - Evolution of Translational …, 2012 - ncbi.nlm.nih.gov
Since the process of mapping and sequencing the human genome began, new
technologies have made it possible to obtain a huge number of molecular measurements …

Mechanical Dyssynchrony Precedes QRS Widening in ATP‐Sensitive K+ Channel–Deficient Dilated Cardiomyopathy

S Yamada, DK Arrell, GC Kane, TJ Nelson… - Journal of the …, 2013 - Am Heart Assoc
Background Contractile discordance exacerbates cardiac dysfunction, aggravating heart
failure outcome. Dissecting the genesis of mechanical dyssynchrony would enable an early …

Systems proteomics for translational network medicine

DK Arrell, A Terzic - Circulation: Cardiovascular Genetics, 2012 - Am Heart Assoc
Arrell and Terzic Network Systems Proteomics o9 growing ever larger. Regardless of
whether gel-based or gelfree methodology is applied, if surveys are quantitative …