Over the years, click and bioorthogonal reactions have been the subject of considerable
research efforts. These high-performance chemical reactions have been developed to meet …

Malignant tumors are characterized by structural and molecular peculiarities providing a
possibility to directionally deliver antitumor drugs with minimal impact on healthy tissues and …

Due to their high reaction rate and reliable selectivity, bioorthogonal click reactions have
been extensively investigated in numerous research fields, such as nanotechnology, drug …

Prostate specific membrane antigen (PSMA) otherwise known as glutamate
carboxypeptidase II (GCPII) is a membrane bound protein that is highly expressed in …

The rational design of a nanoplatform in drug delivery plays a crucial role in determining its
targeting specificity and efficacy in vivo. A conventional approach relies on the surface …

Dual-drug delivery of antiangiogenic and chemotherapeutic drugs can enhance the
therapeutic effect for cancer therapy. Conjugation of methotrexate (MTX) to porous silicon …

Purpose: Methotrexate (MTX) is a first-line drug for rheumatoid arthritis (RA) therapy.
However, MTX monotherapy often results in irreversible joint damage due to its slow onset …

Prostate cancer (PC) is the most prevalent male urogenital cancer worldwide. PC patients
presenting an advanced or metastatic cancer succumb to the disease, even after therapeutic …

Antibody–Drug Conjugates (ADCs) have been through multiple cycles of technological
innovation since the concept was first practically demonstrated~ 40 years ago. Current …

Prostate cancer is one of the most commonly diagnosed men's cancers and remains one of
the leading causes of cancer death. The development of approaches to the treatment of this …