Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Brain edema is a severe stroke complication that is associated with prolonged
hospitalization and poor outcomes. Swollen tissues in the brain compromise cerebral …

The emergence of OpenAI's ChatGPT has put intense spotlight on Generative AI (Gen-AI)
systems and their possible impacts on Academic integrity. This paper provides an overview …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Astrocytes, once believed to serve only as “glue” for the structural support of neurons, have
been demonstrated to serve critical functions for the maintenance and protection of neurons …

Stimulation of Na+/H+ exchanger isoform 1 (NHE1) in astrocytes causes ionic dysregulation
under ischemic conditions. In this study, we created a Nhe1flox/flox (Nhe1f/f) mouse line with …

Ischemic brain injury results from complicated cellular mechanisms. The present therapy for
acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen …

The blood-brain barrier (BBB) plays a critical role in maintaining ion and fluid homeostasis,
essential for brain metabolism and neuronal function. Regulation of nutrient, water, and ion …

Background Chronic cerebral hypoperfusion (CCH) causes white matter damage and
cognitive impairment, in which astrogliosis is the major pathology. However, underlying …

Glial ion transporters are important in regulation of ionic homeostasis, cell volume, and
cellular signal transduction under physiological conditions of the central nervous system …