Programmed DNA elimination in the parasitic nematode Ascaris

B Estrem, J Wang - PLoS pathogens, 2023 - journals.plos.org
In most organisms, the whole genome is maintained throughout the life span. However,
exceptions occur in some species where the genome is reduced during development …

Prevalence of human Schistosoma mansoni infection in endemic regions (2010–2024): a systematic review and meta-analysis

AT Pirzaman, M Sepidarkish, F Alizadeh… - …, 2024 - thelancet.com
Background Schistosoma mansoni infection poses a substantial public health challenge
globally, and the World Health Organization (WHO) aims for the elimination of …

Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection

LE Elizalde-Velázquez, J Schlosser-Brandenburg… - Scientific Reports, 2024 - nature.com
Helminth infections lead to an overdispersion of the parasites in humans as well as in
animals. We asked whether early immune responses against migrating Ascaris larvae are …

Quantifying metabolic activity of Ascaris suum L3 using resazurin reduction

A Kundik, ZD Musimbi, J Krücken, T Hildebrandt… - Parasites & …, 2023 - Springer
Background Helminth infections are an important public health problem in humans and have
an even greater impact on domestic animal and livestock welfare. Current readouts for …

[HTML][HTML] DNA prevalence of eukaryotic parasites with zoonotic potential in urban-associated birds

X Cabodevilla, JE Malo, D Aguirre de Carcer, J Zurdo… - Birds, 2024 - mdpi.com
Simple Summary Zoonoses are a growing threat to human health. Therefore, their
surveillance is especially important in densely populated areas such as cities. Modern cities …

Two-photon NAD(P)H-FLIM reveals unperturbed energy metabolism of Ascaris suum larvae, in contrast to host macrophages upon artemisinin derivatives exposure

ZD Musimbi, A Kundik, J Krücken, AE Hauser… - Scientific Reports, 2025 - nature.com
Soil-transmitted helminths (STH) are widespread, with Ascaris lumbricoides infecting
millions globally. Malaria and STH co-infections are common in co-endemic regions …

Acute Ascaris infection impairs the effector functions of natural killer cells in single and Salmonella co-infected pigs

RM Mugo, L Oser, A Midha, J Adjah, A Kundik… - Scientific Reports, 2024 - nature.com
Natural killer (NK) cells play a key role in defense against Salmonella infections during the
early phase of infection. Our previous work showed that the excretory/secretory products of …

Elevated circulating group-2 innate lymphoid cells expressing activation markers and correlated tryptase AB1 levels in active ascariasis

JF López, J Zakzuk, P Satitsuksanoa… - Frontiers in …, 2024 - frontiersin.org
Introduction Ascaris lumbricoides infection is one of the most common soil-transmitted
helminthiasis and IgE response to this helminth may increase the risk of asthma, bronchial …

Human Ascaris infection is associated with higher frequencies of IL-10 producing B cells

J Zakzuk, JF Lopez, C Akdis, L Caraballo… - PLOS Neglected …, 2024 - journals.plos.org
Introduction Ascaris lumbricoides has dual effects on the immune system of infected hosts.
The IgE response to this parasite has been thoroughly studied, but little is known about …

Dose-response effects of multiple Ascaris suum exposures and their impact on lung protection during larval ascariasis

CCO Amorim, DS Nogueira… - PLOS Neglected …, 2024 - journals.plos.org
Background Human ascariasis is the most prevalent geohelminthiasis worldwide, affecting
approximately 446 million individuals. In regions with endemic prevalence, the majority of …