Uveal melanoma (UM), a rare cancer of the eye, is distinct from cutaneous melanoma by its
etiology, the mutation frequency and profile, and its clinical behavior including resistance to …

Metastasis accounts for the vast majority of morbidity and mortality associated with
melanoma. Evidence suggests melanoma has a predilection for metastasis to particular …

Although metastasis is the leading cause of cancer-related death, it is not clear why some
patients with localized cancer develop metastatic disease after complete resection of their …

Uveal melanoma (UM) is the most common primary intraocular malignancy affecting adults.
Despite successful local treatment of the primary tumour, metastatic disease develops in up …

Background A limitation of positive selection strategies to enrich for circulating tumor cells
(CTCs) is that there might be CTCs with insufficient expression of the surface target marker …

Abstract Purpose: Carcinoma-associated fibroblasts (CAFs) in tumor stroma play an
important role in tumor progression and have been associated with a poor prognosis in oral …

Metastatic dormancy of melanoma has not received sufficient attention, most likely because
once detectable, metastasis is almost invariably fatal and, understandably, the focus has …

Liquid biopsy is a common term referring to circulating tumor cells and other biomarkers,
such as circulating tumor DNA (ctDNA) or extracellular vesicles. Liquid biopsy presents a …

Simple Summary Uveal melanoma is an aggressive cancer that begins in the eye, but often
spreads to distant organs when tumor cells enter the blood. Disease spreads in nearly half …

Ocular melanoma consists of posterior uveal melanoma, iris melanoma and conjunctival
melanoma. These malignancies derive from melanocytes in the uveal tract or conjunctiva …