Laboratory monitoring of hemophilia A treatments: new challenges

PJ Lenting - Blood advances, 2020 - ashpublications.org
Monitoring factor VIII (FVIII) activity has traditionally been complicated by discrepancies
between assays for the various sorts of FVIII molecules. The advent of novel nonfactor …

Thrombin generation and cirrhosis: state of the art and perspectives

A Lebreton, T Sinegre, T Lecompte… - … in thrombosis and …, 2020 - thieme-connect.com
Epidemiological and laboratory studies performed in the last decades have changed our
understanding of coagulopathy in cirrhosis, from a condition at increased risk of …

Thrombin generation assay as a biomarker of cardiovascular outcomes and mortality: a narrative review

LGR Ferreira, RC Figueiredo… - Thrombosis …, 2022 - Elsevier
Cardiovascular diseases (CVDs) are currently the leading cause of death worldwide.
Therefore, there is interest in the search for cardiovascular risk markers that contribute to the …

[HTML][HTML] Prothrombotic disturbances of hemostasis of patients with severe COVID-19: a prospective longitudinal observational study

M Hardy, I Michaux, S Lessire, J Douxfils… - Thrombosis …, 2021 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID-19) is associated with marked albeit variable hemostasis
disturbances and high thrombotic risk [1]. Measurement of plasma D-dimers levels has been …

Combined oral contraceptives containing estradiol valerate vs ethinylestradiol on coagulation: a randomized clinical trial

AH Haverinen, KM Luiro, T Szanto… - Acta Obstetricia et …, 2022 - Wiley Online Library
Introduction Contraceptives containing ethinylestradiol (EE) induce changes in the
coagulation system and are associated with a risk of venous thromboembolism. However …

[HTML][HTML] Hypercoagulability (thrombin generation) in patients with cirrhosis is detected with ST‐Genesia

L Talon, T Sinegre, T Lecompte, B Pereira… - Journal of Thrombosis …, 2020 - Elsevier
Abstract Background Thrombin generation assays (TGAs) performed with calibrated
automated thrombography (CAT) in the presence of thrombomodulin (TM) indicate plasma …

The combination of emicizumab and recombinant factor VIII in plasma: which assays can we use for accurate measurement?

AE Bowyer, RM Maclean… - International Journal of …, 2023 - Wiley Online Library
Introduction The bispecific antibody, emicizumab, is a prophylactic therapy used for the
treatment of haemophilia A (HA). Patients may require additional replacement factor VIII …

[HTML][HTML] Direct oral anticoagulant plasma levels and thrombin generation on ST Genesia system

C Pfrepper, M Metze, A Siegemund, T Klöter… - Research and Practice …, 2020 - Elsevier
Background Monitoring of anticoagulant activity of direct oral anticoagulants (DOACs) can
be necessary in special situations. DOAC plasma levels have a high inter‐and …

[HTML][HTML] Prothrombotic hemostasis disturbances in patients with severe COVID-19: Individual daily data

M Hardy, I Michaux, S Lessire, J Douxfils, JM Dogné… - Data in brief, 2020 - Elsevier
This data article accompanies the manuscript entitled:“Prothrombotic Disturbances of
hemostasis of Patients with Severe COVID-19: a Prospective Longitudinal Observational …

[HTML][HTML] Thrombin generation measured on ST Genesia, a new platform in the coagulation routine lab: Assessment of analytical and between‐subject variation

SR Kristensen, J Nybo, S Pedersen - Research and Practice in Thrombosis …, 2022 - Elsevier
Background The thrombin generation (TG) assay, which measures global coagulation, has
mainly been used as a research tool to investigate thrombotic and bleeding disorders …