Advances in the depth and quality of transcriptome sequencing have revealed many new
classes of long noncoding RNAs (lncRNAs). lncRNA classification has mushroomed to …

Genomes of complex organisms encode an abundance and diversity of long noncoding
RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide variety of regulatory …

Housekeeping (HK) genes are constitutively expressed genes that are required for the
maintenance of basic cellular functions. Despite their importance in the calibration of gene …

Small open reading frames (smORFs) of 100 codons or fewer are usually—if arbitrarily—
excluded from proteome annotations. Despite this, the genomes of many metazoans …

RNA is not only a messenger operating between DNA and protein. Transcription of
essentially the entire eukaryotic genome generates a myriad of non-protein-coding RNA …

Nucleic acids, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), carry genetic
information which is read in cells to make the RNA and proteins by which living things …

The identification of untranslated regions, introns, and coding regions within an organism
remains challenging. We developed a quantitative sequencing-based method called RNA …

In the past century, nearly all of the biological sciences have been directly affected by
discoveries and developments in genetics, a fast-evolving subject with important theoretical …

Transcription and regulation of genes originate from transcription pre-initiation complexes
(PICs). Their structural and positional organization across eukaryotic genomes is unknown …

Highlights•Big data has affected several sectors including biomedicine, life sciences and
scientific research.•Genetics and genomics information are key enablers for predictive and …