Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

The past 25 years of genomics research first revealed which genes are encoded by the
human genome and then a detailed catalogue of human genome variation associated with …

Abstract The Biological General Repository for Interaction Datasets (BioGRID:
https://thebiogrid. org) is an open access database dedicated to the curation and archival …

Forward genetic screens across hundreds of cancer cell lines have started to define the
genetic dependencies of proliferating human cells and how these vary by genotype and …

Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved the life
expectancy for patients with refractory or relapse B cell lymphoma. As for B cell acute …

Gene editing has great potential in treating diseases caused by well-characterized
molecular alterations. The introduction of clustered regularly interspaced short palindromic …

The epigenome dynamically regulates gene expression and guides cellular differentiation
throughout the lifespan of eukaryotic organisms. Recent advances in clustered regularly …

The steady progress in genome editing, especially genome editing based on the use of
clustered regularly interspaced short palindromic repeats (CRISPR) and programmable …

Cancers have an altered metabolism, and there is interest in understanding precisely how
oncogenic transformation alters cellular metabolism and how these metabolic alterations …

As the fourth leading cause of cancer-related death in the world, liver cancer poses a major
threat to human health. Although a growing number of therapies have been approved for the …