Insight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development

TS Sayed, ZH Maayah, HA Zeidan, A Agouni… - Cellular & Molecular …, 2022 - Springer
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates
the toxicities of several environmental pollutants. Decades of research have been carried …

[HTML][HTML] Polysaccharides from edible fungi Pleurotus spp.: advances and perspectives

Z Yin, D Sun-Waterhouse, J Wang, C Ma… - Journal of Future …, 2021 - Elsevier
Pleurotus spp. was one of the most precious and common edible fungi, polysaccharides
were the main active component. The structural, biological activities and structure-activity …

Targeting PGAM1 in cancer: An emerging therapeutic opportunity

GJ Yang, F Tao, HJ Zhong, C Yang, J Chen - European Journal of …, 2022 - Elsevier
Glycolysis is a preferred metabolic pattern of cancer cells. Phosphoglycerate mutase 1
(PGAM1) is a pivotal glycolytic enzyme that catalyzes the reciprocal conversion between 2 …

Pharmacological blockage of the AHR-CYP1A1 axis: a call for in vivo evidence

NR Coelho, AB Pimpão, MJ Correia… - Journal of Molecular …, 2022 - Springer
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that can be
activated by structurally diverse compounds arising from the environment and the microbiota …

[HTML][HTML] Natural products: regulating glucose metabolism and improving insulin resistance

FSA Saadeldeen, Y Niu, H Wang, L Zhou… - Food science and …, 2020 - Elsevier
Compounds with regulating glucose metabolism and improving insulin resistance (IR)
activity are abundant in nature and can be obtained from several sources. They have high …

The antihypertensive effect of Alizarin is achieved by activating VEGFR2/eNOS pathway, attenuating oxidative stress-induced mitochondrial damage and premature …

Y Qian, Y Guo, Y Li, Y Wang, S Guo, Q Niu, M Zhu, P Li - Life Sciences, 2024 - Elsevier
The primary and initial manifestations of hypertension encompass arterial hypoelasticity and
histiocyte senescence. Oxidative stress plays a pivotal role in the progression of …

A comprehensive review of Rubia cordifolia L.: Traditional uses, phytochemistry, pharmacological activities, and clinical applications

M Wen, Q Chen, W Chen, J Yang, X Zhou… - Frontiers in …, 2022 - frontiersin.org
Rubia cordifolia (family: Rubiaceae) L (R. cordifolia) is a perennial botanical drug climbing
vine. As the main part of the traditional Chinese medicine, the rhizome has a long history. A …

The potential mechanisms of Macrocystis pyrifera polysaccharides mitigating type 2 diabetes in rats

RB Jia, ZR Li, L Lin, D Luo, C Chen, M Zhao - Food & Function, 2022 - pubs.rsc.org
Our previous studies have proved that the anti-digestive polysaccharide from Macrocystis
pyrifera possesses potential hypoglycemic and lipid-lowering activities; however, its …

Natural products, a potential source of new drugs discovery to combat obesity and diabetes: their efficacy and multi-targets actions in treatment of these diseases

B Dinda, M Dinda - Natural Products in Obesity and Diabetes: Therapeutic …, 2022 - Springer
Since the prehistoric times, at least 60,000 years back as per fossil records, humans have
been using natural products, such as plants, animals, microorganisms, and marine …

Glucose absorption regulation and mechanism of the compounds in Lilium lancifolium Thunb on Caco-2 cells

X Xu, P Wang, B Wang, M Wang, S Wang, Z Liu… - Food and Chemical …, 2021 - Elsevier
In this paper, the Caco-2 cell was used to study the glucose absorption regulation and
mechanism of kaempferol, caffeic acid and quercetin-3-O-β-D-galactoside in Lilium …