Cannabis, a complex plant: different compounds and different effects on individuals

Z Atakan - Therapeutic advances in psychopharmacology, 2012 - journals.sagepub.com
Cannabis is a complex plant, with major compounds such as delta-9-tetrahydrocannabinol
and cannabidiol, which have opposing effects. The discovery of its compounds has led to …

Adenosine receptors: expression, function and regulation

S Sheth, R Brito, D Mukherjea, LP Rybak… - International journal of …, 2014 - mdpi.com
Adenosine receptors (ARs) comprise a group of G protein-coupled receptors (GPCR) which
mediate the physiological actions of adenosine. To date, four AR subtypes have been …

Cannabinoid receptors: An update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory …

D Haspula, MA Clark - International journal of molecular sciences, 2020 - mdpi.com
The identification of the human cannabinoid receptors and their roles in health and disease,
has been one of the most significant biochemical and pharmacological advancements to …

Development and applications of bioluminescent and chemiluminescent reporters and biosensors

HW Yeh, HW Ai - Annual Review of Analytical Chemistry, 2019 - annualreviews.org
Although fluorescent reporters and biosensors have become indispensable tools in
biological and biomedical fields, fluorescence measurements require external excitation …

Adenosine A2A Receptor as a Drug Discovery Target

M de Lera Ruiz, YH Lim, J Zheng - Journal of medicinal chemistry, 2014 - ACS Publications
The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been
extensively studied during the past few decades because it offers numerous possibilities for …

Cannabinoid receptors CB1 and CB2 form functional heteromers in brain

L Callén, E Moreno, P Barroso-Chinea… - Journal of Biological …, 2012 - ASBMB
Exploring the role of cannabinoid CB 2 receptors in the brain, we present evidence of CB 2
receptor molecular and functional interaction with cannabinoid CB 1 receptors. Using …

Cannabinoids as anticancer therapeutic agents

O Kovalchuk, I Kovalchuk - Cell Cycle, 2020 - Taylor & Francis
The recent announcement of marijuana legalization in Canada spiked many discussions
about potential health benefits of Cannabis sativa. Cannabinoids are active chemical …

Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher‐order oligomers in living cells

N Cabello, J Gandía, DCG Bertarelli… - Journal of …, 2009 - Wiley Online Library
G protein‐coupled receptors are known to form homo‐and heteromers at the plasma
membrane, but the stoichiometry of these receptor oligomers are relatively unknown. Here …

Functionally selective cannabinoid receptor signalling: therapeutic implications and opportunities

B Bosier, GG Muccioli, E Hermans… - Biochemical …, 2010 - Elsevier
The CB1 and CB2 cannabinoid receptors are G protein-coupled receptors (GPCRs)
recognized by a variety of endogenous ligands and activating multiple signalling pathways …

Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland

S González, D Moreno-Delgado, E Moreno… - PLoS …, 2012 - journals.plos.org
The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by
the retina into hormonal signals that are transmitted to the rest of the neuronal system in the …