Cardiovascular disease in patients with severe mental illness

RE Nielsen, J Banner, SE Jensen - Nature Reviews Cardiology, 2021 - nature.com
Individuals diagnosed with schizophrenia or bipolar disorder have a life expectancy 15–20
years shorter than that in the general population. The rate of unnatural deaths, such as …

The role of sleep disorders in cardiovascular diseases: Culprit or accomplice?

Q Wang, X Wang, C Yang, L Wang - Life sciences, 2021 - Elsevier
Sleep disorders frequently comorbid with several cardiovascular diseases (CVDs), attracting
increasing scientific attention and interest. Sleep disorders include insomnia, sleep …

Effect of polygenic risk for schizophrenia on cardiac structure and function: a UK Biobank observational study

T Pillinger, EF Osimo, A de Marvao, M Shah… - The Lancet …, 2023 - thelancet.com
Background Cardiovascular disease is a major cause of excess mortality in people with
schizophrenia. Several factors are responsible, including lifestyle and metabolic effects of …

CB1R-stabilized NLRP3 inflammasome drives antipsychotics cardiotoxicity

L Li, P Gao, X Tang, Z Liu, M Cao, R Luo, X Li… - Signal transduction and …, 2022 - nature.com
Long-term use of antipsychotics is a common cause of myocardial injury and even sudden
cardiac deaths that often lead to drug withdrawn or discontinuation. Mechanisms underlying …

Exploring the relationship between schizophrenia and cardiovascular disease: a genetic correlation and multivariable Mendelian randomization study

RR Veeneman, JM Vermeulen… - Schizophrenia …, 2022 - academic.oup.com
Individuals with schizophrenia have a reduced life-expectancy compared to the general
population, largely due to an increased risk of cardiovascular disease (CVD). Clinical and …

Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case–control study

EF Osimo, M Sweeney, A de Marvao, A Berry… - Translational …, 2021 - nature.com
Cardiovascular diseases are the leading cause of death in schizophrenia. Patients with
schizophrenia show evidence of concentric cardiac remodelling (CCR), defined as an …

Clinical heart failure among patients with and without severe mental illness and the association with long-term outcomes

C Polcwiartek, D Loewenstein, DJ Friedman… - Circulation: Heart …, 2021 - Am Heart Assoc
Background: Patients with severe mental illness (SMI) including schizophrenia, bipolar
disorder, and severe depression have earlier onset of cardiovascular risk factors …

Severe mental illness: cardiovascular risk assessment and management

C Polcwiartek, K O'Gallagher, DJ Friedman… - European Heart …, 2024 - academic.oup.com
Patients with severe mental illness (SMI) including schizophrenia and bipolar disorder die
on average 15–20 years earlier than the general population often due to sudden death that …

Schizophrenia hypothesis: Autonomic nervous system dysregulation of fetal and adult immune tolerance

T Carnac - Frontiers in systems neuroscience, 2022 - frontiersin.org
The autonomic nervous system can control immune cell activation via both sympathetic
adrenergic and parasympathetic cholinergic nerve release of norepinephrine and …

Impaired coronary microvascular reactivity in youth with bipolar disorder

KG Kennedy, NR Ghugre, I Roifman, X Qi… - Psychological …, 2024 - cambridge.org
BackgroundCardiovascular disease (CVD) is excessively prevalent and premature in
bipolar disorder (BD), even after controlling for traditional cardiovascular risk factors. The …