The t (8; 21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The
translocation results in an in‐frame fusion of two genes, resulting in a fusion protein of one N …

Both genetic and epigenetic mechanisms are obligatory for physiologically responsive
activation and suppression of genes that govern cell growth, proliferation, phenotype and …

Gene fusions involving members of the RAF family of protein kinases have recently been
identified as characteristic aberrations of low-grade astrocytomas, the most common tumors …

Parathyroid hormone-like hormone (PTHLH) is an important chondrogenic regulator;
however, the gene has not been directly linked to human disease. We studied a family with …

RUNX1 a member of the family of runt related transcription factors (RUNX), is essential for
hematopoiesis. The expression of RUNX1 gene is controlled by two promoters; the distal P1 …

The regulatory machinery that governs genetic and epigenetic control of gene expression for
biological processes and cancer is organized in nuclear microenvironments. Strategic …

Background RUNX1 gene, a master regulator of the hematopoietic process, participates in
pathological conditions as a partner for several genes in chromosomal translocations. One …

One of the most frequent chromosomal translocation found in patients with acute myeloid
leukemia (AML) is the t (8; 21). This translocation involves the RUNX1 and ETO genes. The …

In this work, we analyzed the association between RUNX1 gene expression and the
accessibility of BCR3, one of RUNX1 gene breakpoint regions involved in the chromosomal …

Background Human RUNX1 gene is one of the most frequent target for chromosomal
translocations associated with acute myeloid leukemia (AML) and acute lymphoid leukemia …