The connection between inflammation and tumorigenesis is well-established and in the last
decade has received a great deal of supporting evidence from genetic, pharmacological …

Cancer remains to be one of the leading causes of death in the United States and around
the world. The advent of modern drug-targeted therapies has undeniably improved cancer …

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

Along with the development of marine biological pharmaceutical research, high‐effective
and low‐toxic drugs and functional foods isolated from marine organisms have become a …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors that are involved in regulating glucose and lipid homeostasis, inflammation …

Recent scientific advances have contributed much to the dissection of the complex
molecular and cellular pathways involved in the connection between cancer and …

Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …

Because metastasis is associated with the majority of cancer-related deaths, its prevention is
a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the …

Context Aspirin reduces risk of colorectal neoplasia in randomized trials and inhibits tumor
growth and metastases in animal models. However, the influence of aspirin on survival after …

The prognosis of breast cancer in young women is influenced by reproductive history.
Women diagnosed within 5 years postpartum have worse prognosis than nulliparous …