Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that
can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to …

The past decade has seen significant advances in our understanding of Hedgehog (HH)
signaling pathway in various biological events. HH signaling pathway exerts its biological …

Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive tumor and the
sixth most common cancer worldwide. Current treatment strategies for HNSCC are surgery …

Fibroblast growth factors (FGFs) are a family of proteins possessing paracrine, autocrine, or
endocrine functions in a variety of biological processes, including embryonic development …

Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …

Background Emerging evidence demonstrates that lncRNAs play pivotal roles in tumor
energy metabolism; however, the detailed mechanisms of lncRNAs in the regulation of …

Background Oral squamous cell carcinoma (OSCC) is a malignant oral cavity neoplasm that
affects many people, especially in developing countries. Despite several advances that have …

Protocatechuic acid (PCA) is a natural phenolic acid present in daily vegetables and fruits.
Notably, PCA was demonstrated to inhibit the biological function of SerpinB9 (Sb9) and …

We conducted a genome-wide association study (GWAS) in a multiethnic cohort of 920 at-
risk infants for retinopathy of prematurity (ROP), a major cause of childhood blindness …