The current model of human breast cancer progression proposes a linear multi‐step process
which initiates as flat epithelial atypia (FEA), progresses to atypical ductal hyperplasia …

This Review summarizes and evaluates the current evidence for the cellular origins of breast
cancer subtypes identified by different approaches such as histology, molecular pathology …

Epithelial-to-mesenchymal transition (EMT) is a critical event in the progression toward
cancer metastasis. The intermediate filament protein vimentin is an important marker of EMT …

Purpose: To elucidate molecular pathways contributing to metastatic cancer progression
and poor clinical outcome in serous ovarian cancer. Experimental Design: Poor survival …

Introduction The importance of the tumor microenvironment in breast cancer has been
increasingly recognized. Critical molecular changes in the tumor stroma accompanying …

The transition from ductal carcinoma in situ to invasive ductal carcinoma is a key event in
breast cancer progression that is still not well understood. To discover the microRNAs …

Progress in understanding tumor stromal biology has been constrained in part because
cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell-type …

New cancer therapies are likely to arise from an in-depth understanding of the signaling
networks influencing tumor initiation, progression and metastasis. We show a fundamental …

Purpose While the mortality associated with ductal carcinoma in situ (DCIS) is minimal, the
risk of ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) is …

A method of treating a patient who has non-small cell lung carcinoma (NSCLC), lung cancer,
gastric cancer, and/or glioblastoma includes administering to said patient a composition …