Malaria is caused by Plasmodium protozoa that are transmitted by anopheline mosquitoes.
Plasmodium sporozoites are released with saliva when an infected female mosquito takes a …

The Plasmodium liver stage represents a vulnerable therapeutic target to prevent disease
progression as the parasite resides in the liver before clinical representation caused by …

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must
navigate the host skin and vasculature to infect the liver. This journey requires distinct …

Malaria parasites have a complex life cycle featuring diverse developmental strategies, each
uniquely adapted to navigate specific host environments. Here we use single-cell …

Abstract Background Antibodies targeting Plasmodium falciparum sporozoites play a key
role in human immunity to malaria. However, antibody mechanisms that neutralize …

Parasitic protozoa of the phylum Apicomplexa cause a range of human and animal
diseases. Their complex life cycles–often heteroxenous with sexual and asexual phases in …

Rare and potent monoclonal antibodies (mAbs) against the Plasmodium falciparum (Pf)
circumsporozoite protein (CSP) on infective sporozoites (SPZ) preferentially bind the PfCSP …

The capacity to migrate is fundamental to multicellular and single-celled life. Apicomplexan
parasites, an ancient protozoan clade that includes malaria parasites (Plasmodium) and …

Malaria is initiated when infected anopheline mosquitoes inoculate sporozoites as they
probe for blood. It is thought that all infected mosquitoes are equivalent in terms of their …

Highlights•Plasmepsin IX and X are essential for parasite egress and invasion in rodent and
human malaria throughout the Plasmodium life cycle.•Efficient genetic manipulation of …