A synopsis on aging—Theories, mechanisms and future prospects

JP da Costa, R Vitorino, GM Silva, C Vogel… - Ageing research …, 2016 - Elsevier
Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Gender, aging and longevity in humans: an update of an intriguing/neglected scenario paving the way to a gender-specific medicine

R Ostan, D Monti, P Gueresi, M Bussolotto… - Clinical …, 2016 - portlandpress.com
Data showing a remarkable gender difference in life expectancy and mortality, including
survival to extreme age, are reviewed starting from clinical and demographic data and …

Inflamm-ageing

E Cevenini, D Monti, C Franceschi - Current Opinion in Clinical …, 2013 - journals.lww.com
The possibility to control inflamm-ageing represents a powerful tool to modulate and
counteract the major age-related pathologies and it is urgent to clarify the shady areas of the …

The business of anti-aging science

JP De Magalhães, M Stevens, D Thornton - Trends in biotechnology, 2017 - cell.com
Age-related conditions are the leading causes of death and health-care costs. Reducing the
rate of aging would have enormous medical and financial benefits. Myriad genes and …

Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

F Olivieri, L Spazzafumo, G Santini, R Lazzarini… - Mechanisms of ageing …, 2012 - Elsevier
Circulating microRNAs (miRs) have been investigated as diagnostic/prognostic biomarkers
in human diseases. However, little is known about their expression throughout the aging …

Inflammaging and human longevity in the omics era

D Monti, R Ostan, V Borelli, G Castellani… - Mechanisms of Ageing …, 2017 - Elsevier
Inflammaging is a recent theory of aging originally proposed in 2000 where data and
conceptualizations regarding the aging of the immune system (immunosenescence) and the …

In pursuit of healthy aging: effects of nutrition on brain function

TM Melzer, LM Manosso, S Yau, J Gil-Mohapel… - International journal of …, 2021 - mdpi.com
Consuming a balanced, nutritious diet is important for maintaining health, especially as
individuals age. Several studies suggest that consuming a diet rich in antioxidants and anti …

N-glycomic biomarkers of biological aging and longevity: a link with inflammaging

F Dall'Olio, V Vanhooren, CC Chen, PE Slagboom… - Ageing research …, 2013 - Elsevier
Glycosylation is a frequent co/post-translational modification of proteins which modulates a
variety of biological functions. The analysis of N-glycome, ie the sugar chains N-linked to …

Emerging insights into the metabolic alterations in aging using metabolomics

S Srivastava - Metabolites, 2019 - mdpi.com
Metabolomics is the latest 'omics' technology and systems biology science that allows for
comprehensive profiling of small-molecule metabolites in biological systems at a specific …

Glyoxalase in ageing

M Xue, N Rabbani, PJ Thornalley - Seminars in cell & developmental …, 2011 - Elsevier
The glyoxalase system has been studied since 1913. The biochemical function of this
enzymatic system is the metabolism of reactive dicarbonyl metabolites, glyoxal and …