Biochemical systems theory: a review
EO Voit - International Scholarly Research Notices, 2013 - Wiley Online Library
Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …
that facilitate the analysis of dynamic biological systems. This paper depicts major …
The (mathematical) modeling process in biosciences
In this communication, we introduce a general framework and discussion on the role of
models and the modeling process in the field of biosciences. The objective is to sum up the …
models and the modeling process in the field of biosciences. The objective is to sum up the …
[图书][B] Biomolecular networks: methods and applications in systems biology
Alternative techniques and tools for analyzing biomolecular networks With the recent rapid
advances in molecular biology, high-throughput experimental methods have resulted in …
advances in molecular biology, high-throughput experimental methods have resulted in …
Two-stage flux balance analysis of metabolic networks for drug target identification
Background Efficient identification of drug targets is one of major challenges for drug
discovery and drug development. Traditional approaches to drug target identification include …
discovery and drug development. Traditional approaches to drug target identification include …
Optimization of biochemical systems through mathematical programming: Methods and applications
In this work we present a general (mono and multiobjective) optimization framework for the
technological improvement of biochemical systems. The starting point of the method is a …
technological improvement of biochemical systems. The starting point of the method is a …
Multiplicity of mathematical modeling strategies to search for molecular and cellular insights into bacteria lung infection
Even today two bacterial lung infections, namely pneumonia and tuberculosis, are among
the 10 most frequent causes of death worldwide. These infections still lack effective …
the 10 most frequent causes of death worldwide. These infections still lack effective …
A systems-theoretical framework for health and disease: inflammation and preconditioning from an abstract modeling point of view
EO Voit - Mathematical biosciences, 2009 - Elsevier
Modern advances in molecular biology have produced enormous amounts of data
characterizing physiological and disease states in cells and organisms. While bioinformatics …
characterizing physiological and disease states in cells and organisms. While bioinformatics …
Mathematical formalisms based on approximated kinetic representations for modeling genetic and metabolic pathways
R Alves, E Vilaprinyo… - Biotechnology and …, 2008 - Taylor & Francis
There is a renewed interest in obtaining a systemic understanding of metabolism, gene
expression and signal transduction processes, driven by the recent research focus on …
expression and signal transduction processes, driven by the recent research focus on …
Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive …
G Guillén-Gosálbez, A Sorribas - BMC bioinformatics, 2009 - Springer
Background Optimization methods allow designing changes in a system so that specific
goals are attained. These techniques are fundamental for metabolic engineering. However …
goals are attained. These techniques are fundamental for metabolic engineering. However …