How bacteria establish and maintain outer membrane lipid asymmetry

WB Tan, SS Chng - Annual Review of Microbiology, 2024 - annualreviews.org
Gram-negative bacteria build an asymmetric outer membrane (OM), with
lipopolysaccharides (LPS) and phospholipids (PLs) occupying the outer and inner leaflets …

RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence

K Wu, X Lin, Y Lu, R Dong, H Jiang… - Nature …, 2024 - nature.com
Abstract Hypervirulent Klebsiella pneumoniae (HvKP) is an emerging bacterial pathogen
causing invasive infection in immune-competent humans. The hypervirulence is strongly …

Lipid Trafficking in Diverse Bacteria

JCC Chou, LMK Dassama - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus Lipids are essential for life and serve as cell envelope components, signaling
molecules, and nutrients. For lipids to achieve their required functions, they need to be …

Investigating lipid transporter protein and lipid interactions using variable temperature electrospray ionization, ultraviolet photodissociation mass spectrometry, and …

VK James, BJ Voss, A Helms, MS Trent… - Analytical …, 2024 - ACS Publications
Gram-negative bacteria develop and exhibit resistance to antibiotics, owing to their highly
asymmetric outer membrane maintained by a group of six proteins comprising the Mla …

[HTML][HTML] β-barrel membrane proteins fold via hybrid-barrel intermediate states

A Hartojo, MT Doyle - Current Opinion in Structural Biology, 2024 - Elsevier
Gram-negative bacteria and eukaryotic organelles of bacterial origin contain outer
membrane proteins that possess a transmembrane “β-barrel” domain. The conserved β …

The Mla system and its role in maintaining outer membrane barrier function in Stenotrophomonas maltophilia

X Coves, U Mamat, O Conchillo-Solé… - Frontiers in Cellular …, 2024 - frontiersin.org
Stenotrophomonas maltophilia are ubiquitous Gram-negative bacteria found in both natural
and clinical environments. It is a remarkably adaptable species capable of thriving in various …

Dynamic players and intricate interactions: An integrated investigation of the Mla lipid transport system

D Ng, TF Moraes - Journal of Biological Chemistry, 2023 - ASBMB
The Maintenance of outer membrane (OM) Lipid Asymmetry system mediates retrograde
phospholipid transport from the OM to the inner membrane (IM) in Gram-negative bacteria …

Development of mass spectrometry strategies for intact protein applications

VK James - 2024 - repositories.lib.utexas.edu
Herein the use of high resolution Orbitrap mass spectrometry for accurate mass assignment
and structural characterization of proteins is described. An advanced fragmentation method …