Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

Between the 1930s and 50s, evolutionary biologists developed a successful theory of why
organisms age, firmly rooted in population genetic principles. By the 1980s the evolution of …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study …

Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

Abstract The Industrial Revolution and the accompanying nutritional, epidemiological and
demographic transitions have profoundly changed human ecology and biology, leading to …

Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular
disease, and type 2 diabetes are among a long list of “lifestyle” diseases that were rare …

Life history theory has become a prominent framework in the evolutionary social sciences,
and the concept of trade-offs, the cornerstone of life history theory in studies on non-human …

Between the 1930s and 1950s, scientists developed key principles of population genetics to
try and explain the aging process. Almost a century later, these aging theories, including …

The antagonistic pleiotropy hypothesis posits that natural selection for pleiotropic mutations
that confer earlier or more reproduction but impair the post-reproductive life causes aging …

There is a global epidemic of chronic kidney disease (CKD) characterized by a progressive
loss of nephrons, ascribed in large part to a rising incidence of hypertension, metabolic …