Autophagy, inflammation, and immune dysfunction in the pathogenesis of pancreatitis
Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known
about its pathogenesis, and there is no specific or effective treatment. Its development …
about its pathogenesis, and there is no specific or effective treatment. Its development …
[HTML][HTML] Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models
MA Heinrich, AMRH Mostafa, JP Morton… - Advanced drug delivery …, 2021 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …
Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells
Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate
intracellular signalling pathways that promote cancer cell survival and tumour growth …
intracellular signalling pathways that promote cancer cell survival and tumour growth …
Ins1 Cre knock-in mice for beta cell-specific gene recombination
Aims/hypothesis Pancreatic beta cells play a central role in the control of glucose
homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues …
homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues …
Integrative regulation of physiology by histone deacetylase 3
Cell-type-specific gene expression is physiologically modulated by the binding of
transcription factors to genomic enhancer sequences, to which chromatin modifiers such as …
transcription factors to genomic enhancer sequences, to which chromatin modifiers such as …
Pancreatic cancer cells upregulate LPAR4 in response to isolation stress to promote an ECM-enriched niche and support tumour initiation
C Wu, T Rakhshandehroo, HI Wettersten… - Nature cell …, 2023 - nature.com
Defining drivers of tumour initiation can provide opportunities to control cancer progression.
Here we report that lysophosphatidic acid receptor 4 (LPAR4) becomes transiently …
Here we report that lysophosphatidic acid receptor 4 (LPAR4) becomes transiently …
Characterization of Cre recombinase models for the study of adipose tissue
The study of adipose tissue in vivo has been significantly advanced through the use of
genetic mouse models. While the aP2-CreBI and aP2-CreSalk lines have been widely used …
genetic mouse models. While the aP2-CreBI and aP2-CreSalk lines have been widely used …
Regeneration and repair of the exocrine pancreas
LC Murtaugh, MD Keefe - Annual review of physiology, 2015 - annualreviews.org
Pancreatitis is caused by inflammatory injury to the exocrine pancreas, from which both
humans and animal models appear to recover via regeneration of digestive enzyme …
humans and animal models appear to recover via regeneration of digestive enzyme …
Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function
Cold temperatures induce formation of beige adipocytes, which convert glucose and fatty
acids to heat, and may increase energy expenditure, reduce adiposity and lower blood …
acids to heat, and may increase energy expenditure, reduce adiposity and lower blood …
Metabolic pitfalls of CNS Cre-based technology
E Harno, EC Cottrell, A White - Cell metabolism, 2013 - cell.com
Nestin-Cre mice have a significant metabolic phenotype that is hard to discern from current
literature. Indeed, the Cre-lox system has numerous problems that can affect physiological …
literature. Indeed, the Cre-lox system has numerous problems that can affect physiological …