Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications
Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
Electrochemical transformations catalyzed by cytochrome P450s and peroxidases
Cytochrome P450s (Cyt P450s) and peroxidases are enzymes featuring iron heme cofactors
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …
Protein bioelectronics: A review of what we do and do not know
We review the status of protein-based molecular electronics. First, we define and discuss
fundamental concepts of electron transfer and transport in and across proteins and …
fundamental concepts of electron transfer and transport in and across proteins and …
Cytochrome P450 (CYP) enzymes and the development of CYP biosensors
E Schneider, DS Clark - Biosensors and Bioelectronics, 2013 - Elsevier
Cytochrome P450s (CYPs) are a large family of heme-containing monooxygenase enzymes
involved in the first-pass metabolism of drugs and foreign chemicals in the body. CYP …
involved in the first-pass metabolism of drugs and foreign chemicals in the body. CYP …
An overview of cytochrome P450 immobilization strategies for drug metabolism studies, biosensing, and biocatalytic applications: challenges and opportunities
Cytochrome P450s (P450s or CYPs) are a large superfamily of ubiquitous heme proteins.
Consistent with their natural roles in oxidative metabolism of a broad range of substrates …
Consistent with their natural roles in oxidative metabolism of a broad range of substrates …
Efficient bioelectronic actuation of the natural catalytic pathway of human metabolic cytochrome P450s
Cytochrome (cyt) P450s comprise the enzyme superfamily responsible for human oxidative
metabolism of a majority of drugs and xenobiotics. Electronic delivery of electrons to cyt …
metabolism of a majority of drugs and xenobiotics. Electronic delivery of electrons to cyt …
Resonance Raman and electrocatalytic behavior of thiolate and imidazole bound iron porphyrin complexes on self assembled monolayers: Functional modeling of …
Electrodes bearing thiolate and imidazole coordinated iron porphyrin catalysts are
constructed and characterized using resonance Raman spectroscopy, absorption …
constructed and characterized using resonance Raman spectroscopy, absorption …
Electrochemical Biosensor for Evaluation of Environmental Pollutants Toxicity
MS Islam, K Sazawa, K Sugawara, H Kuramitz - Environments, 2023 - mdpi.com
Electrochemical biosensors that combine high selectivity of biochemical affinity with precise
electrochemical detection are one of the most necessary and powerful tools for assessing …
electrochemical detection are one of the most necessary and powerful tools for assessing …
Bielectrode Strategy for Determination of CYP2E1 Catalytic Activity: Electrodes with Bactosomes and Voltammetric Determination of 6-Hydroxychlorzoxazone
AV Kuzikov, RA Masamrekh, TA Filippova… - Biomedicines, 2024 - mdpi.com
We describe a bielectrode system for evaluation of the electrocatalytic activity of cytochrome
P450 2E1 (CYP2E1) towards chlorzoxazone. One electrode of the system was employed to …
P450 2E1 (CYP2E1) towards chlorzoxazone. One electrode of the system was employed to …
Bioelectronic delivery of electrons to cytochrome P450 enzymes
S Krishnan, JB Schenkman… - The Journal of Physical …, 2011 - ACS Publications
Cytochrome P450s (cyt P450s) are the major oxidative enzymes in human oxidative
metabolism of drugs and xenobiotic chemicals. In nature, the iron heme cyt P450s utilize …
metabolism of drugs and xenobiotic chemicals. In nature, the iron heme cyt P450s utilize …