Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Arginase, a binuclear manganese metalloenzyme in the urea, catalyzes the hydrolysis of L-
arginine to urea and L-ornithine. Both isoforms, arginase 1 and arginase 2 perform …

Aging leads to a multitude of changes in the cardiovascular system, including systolic
hypertension, increased central vascular stiffness, and increased pulse pressure. In this …

Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Oxidized low-density lipoproteins increase arginase activity and reciprocally decrease
endothelial NO in human aortic endothelial cells. Here, we demonstrate that vascular …

Nitric oxide (NO) inhibits the mitochondrial respiratory chain, resulting in inhibition of ATP
production, increased oxidant production and increased susceptibility to cell death. NO …

Endothelial function is impaired in aging because of a decrease in NO bioavailability. This
may be, in part, attributable to increased arginase activity, which reciprocally regulates NO …

Vascular and associated ventricular stiffness is one of the hallmarks of the aging
cardiovascular system. Both an increase in reactive oxygen species production and a …

Oxidized low-density lipoprotein (OxLDL) impairs NO signaling and endothelial function,
and contributes to the pathogenesis of atherosclerosis. Arginase reciprocally regulates NO …

AIMS: Arginase II regulates NOS activity by competing for the substrate l-arginine. Oxidized
LDL (OxLDL) is a proatherogenic molecule that activates arginase II. We tested the …