p53 regulates diverse tissue-specific outcomes to endogenous DNA damage in mice
RJ Hill, N Bona, J Smink, HK Webb, A Crisp… - Nature …, 2024 - nature.com
DNA repair deficiency can lead to segmental phenotypes in humans and mice, in which
certain tissues lose homeostasis while others remain seemingly unaffected. This may be …
certain tissues lose homeostasis while others remain seemingly unaffected. This may be …
Genetic risk factors for late-onset Alzheimer's disease drive senescence in female tauopathy mice
T Hensley-McBain, ME Orr - Neuron, 2024 - cell.com
Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular
senescence, a hallmark of aging, in a tau-and sex-dependent manner. Mechanistic insights …
senescence, a hallmark of aging, in a tau-and sex-dependent manner. Mechanistic insights …
Inhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage
Y Sun, S Zou, X Xu, S Xu, H Sun, M Tang, W Kong… - Neuroscience …, 2024 - Springer
Although cisplatin is a widely used chemotherapeutic agent, it is severely toxic and causes
irreversible hearing loss, restricting its application in clinical settings. This study aimed to …
irreversible hearing loss, restricting its application in clinical settings. This study aimed to …
Loss of killifish cGAS/STING function attenuates cellular senescence and age-related signatures but does not extend organismal life span
E Ballhysa, R Ripa, N Hochhard, TTM Nguyen… - bioRxiv, 2024 - biorxiv.org
The cGAS/STING pathway is a central innate immune signaling pathway whose chronic
activation has been implicated in numerous age-related pathologies, yet its impact on life …
activation has been implicated in numerous age-related pathologies, yet its impact on life …