The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

Glial cells and neurons are engaged in a continuous and highly regulated bidirectional
dialog. A remarkable example is the control of myelination. Oligodendrocytes in the central …

Neuregulin-1 (Nrg1) provides a key axonal signal that regulates Schwann cell proliferation,
migration and myelination through binding to ErbB2/3 receptors. The analysis of a number of …

Highlights•Remak Schwann cells ensheath multiple small caliber axons.•Remak Schwann
cells are critical for peripheral nerve development, maintenance, and regeneration.•Genetic …

Recent findings indicate that nociceptive nerves are not “free”, but similar to touch and
pressure sensitive nerves, terminate in an end-organ in mice. This sensory structure consists …

A key component in the response of the nervous system to injury is the proliferation and
switch to a “proinflammatory” phenotype by microglia (microgliosis). In situations where the …

Joint degeneration observed in the rat monoiodoacetate (MIA) model of osteoarthritis shares
many histological features with the clinical condition. The accompanying pain phenotype …

Neuregulin-1 (NRG1) plays a crucial role in axoglial signaling during the development of the
peripheral nervous system, but its importance in adulthood after peripheral nerve injury …