Self-nano-emulsifying drug-delivery systems: From the development to the current applications and challenges in oral drug delivery

AB Buya, A Beloqui, PB Memvanga, V Préat - Pharmaceutics, 2020 - mdpi.com
Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …

Solid self emulsifying drug delivery system: Superior mode for oral delivery of hydrophobic cargos

I Maji, S Mahajan, A Sriram, P Medtiya… - Journal of Controlled …, 2021 - Elsevier
A significant proportion of recently approved drug molecules possess poor aqueous
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …

Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs

RN Gursoy, S Benita - Biomedicine & pharmacotherapy, 2004 - Elsevier
The oral delivery of hydrophobic drugs presents a major challenge because of the low
aqueous solubility of such compounds. Self-emulsifying drug delivery systems (SEDDS) …

Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments

DS Bernardi, TA Pereira, NR Maciel, J Bortoloto… - Journal of …, 2011 - Springer
Background Nanoemulsions have practical application in a multitude of commercial areas,
such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice …

[图书][B] Microencapsulation: methods and industrial applications

S Benita - 2005 - taylorfrancis.com
Presenting breakthrough research pertinent to scientists in a wide range of disciplines-from
medicine and biotechnology to cosmetics and pharmacy-this Second Edition provides …

Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability

K Kohli, S Chopra, D Dhar, S Arora, RK Khar - Drug discovery today, 2010 - Elsevier
Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of
poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them …

Successfully improving ocular drug delivery using the cationic nanoemulsion, novasorb

F Lallemand, P Daull, S Benita… - Journal of drug …, 2012 - Wiley Online Library
Topical ophthalmic delivery of active ingredients can be achieved using cationic
nanoemulsions. In the last decade, Novagali Pharma has successfully developed and …

Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs

T Gershanik, S Benita - European journal of pharmaceutics and …, 2000 - Elsevier
The main purpose of this review is to provide a current and general overview of the existing
self-dispersing formulations resulting from dilution into emulsions, microemulsions and …

Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A

MH El-Shabouri - International journal of pharmaceutics, 2002 - Elsevier
In this study, cyclosporin-A (Cy-A) a highly lipophilic, poorly absorbable drug can be
prepared easily and reproducibly as positively and negatively charged nanoparticles with …

Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration

K Manjunath, V Venkateswarlu - Journal of Controlled Release, 2005 - Elsevier
Clozapine, a lipophilic effective atypical antipsychotic drug, has very poor oral bioavailability
(< 27%) due to first pass effect. Clozapine solid lipid nanoparticles have been developed …