BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

Ferroptosis is a new type of programmed cell death characterized by intracellular iron
accumulation and lipid peroxidation that leads to oxidative stress and cell death. The …

Kinetics and molecular mechanisms of GPx-type enzymes are reviewed with emphasis on
structural features relevant to efficiency and specificity. In Sec-GPxs the reaction takes place …

Rapid increase in aging populations is an urgent problem because older adults are more
likely to suffer from disabilities and age-related diseases (ARDs), burdening healthcare …

Thiol peroxidases comprise glutathione peroxidases (GPx) and peroxiredoxins (Prx). The
enzymes of both families reduce hydroperoxides with thiols by enzyme-substitution …

The protozoan parasites Trypanosoma brucei and Trypanosoma cruzi are the causative
agents of African trypanosomiasis and Chagas disease, respectively. These are debilitating …

Cys-based redox regulation was long regarded a major adjustment mechanism of
photosynthesis and metabolism in plants, but in the recent years, its scope has broadened to …

Tryparedoxin peroxidases, distant relatives of glutathione peroxidase 4 in higher
eukaryotes, are responsible for the detoxification of lipid-derived hydroperoxides in African …

Cysteine glutathione peroxidases (CysGPxs) control oxidative stress levels by reducing
hydroperoxides at the expense of cysteine thiol (‐SH) oxidation, and the recovery of their …

Chagas Disease, African sleeping sickness, and leishmaniasis are neglected diseases
caused by pathogenic trypanosomatid parasites, which have a considerable impact on …