Human papillomaviruses: diversity, infection and host interactions

AA McBride - Nature Reviews Microbiology, 2022 - nature.com
Human papillomaviruses (HPVs) are an ancient and highly successful group of viruses that
have co-evolved with their host to replicate in specific anatomical niches of the stratified …

HPV post-infection microenvironment and cervical cancer

Y Yuan, X Cai, F Shen, F Ma - Cancer Letters, 2021 - Elsevier
Human papillomavirus (HPV) is the most common sexually transmitted virus worldwide.
More than 99% of cervical cancer cases are associated with certain types of HPVs, termed …

The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation

JA Scarth, MR Patterson… - Journal of General …, 2021 - microbiologyresearch.org
Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

Persistent human papillomavirus infection

AN Della Fera, A Warburton, TL Coursey, S Khurana… - Viruses, 2021 - mdpi.com
Simple Summary The success of HPV as an infectious agent lies not within its ability to
cause disease, but rather in the adeptness of the virus to establish long-term persistent …

Human papillomaviruses as infectious agents in gynecological cancers. Oncogenic properties of viral proteins

DA Haręża, JR Wilczyński, E Paradowska - International journal of …, 2022 - mdpi.com
Human papillomaviruses (HPVs), which belong to the Papillomaviridae family, constitute a
group of small nonenveloped double-stranded DNA viruses. HPV has a small genome that …

Role of the JAK/STAT pathway in cervical cancer: its relationship with HPV E6/E7 oncoproteins

A Gutiérrez-Hoya, I Soto-Cruz - Cells, 2020 - mdpi.com
The janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway is associated with the regulation of essential cellular mechanisms, such as …

The not-so-good, the bad and the ugly: HPV E5, E6 and E7 oncoproteins in the orchestration of carcinogenesis

O Basukala, L Banks - Viruses, 2021 - mdpi.com
Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway

S Miyauchi, SS Kim, RN Jones, L Zhang, K Guram… - Cell reports, 2023 - cell.com
The role that human papillomavirus (HPV) oncogenes play in suppressing responses to
immunotherapy in cancer deserves further investigation. In particular, the effects of HPV E5 …

Biology of HPV mediated carcinogenesis and tumor progression

PF Cosper, S Bradley, Q Luo, RJ Kimple - Seminars in radiation oncology, 2021 - Elsevier
Human papillomavirus (HPV) is a ubiquitous DNA virus that infects squamous epithelia.
Though HPV only encodes 8 genes, it is capable of causing cellular transformation and …

JAK/STAT signaling and cervical cancer: from the cell surface to the nucleus

A Valle-Mendiola, A Gutiérrez-Hoya, I Soto-Cruz - Genes, 2023 - mdpi.com
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling
pathway constitutes a rapid signaling module from the cell surface to the nucleus, and …