Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

5-Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage
pathway. The MTAP gene is frequently deleted in human cancers because of its …

Post-translational arginine methylation is responsible for regulation of many biological
processes. The protein arginine methyltransferase 5 (PRMT5, also known as Hsl7, Jbp1 …

Abstract Polycomb repressive complex 2 (PRC2) consists of three core subunits, EZH2, EED
and SUZ12, and plays pivotal roles in transcriptional regulation. The catalytic subunit EZH2 …

The PRMT5• MTA complex has recently emerged as a new synthetically lethal drug target
for the treatment of MTAP-deleted cancers. Here, we report the discovery of development …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …

Summary Protein arginine methyltransferase 5 (PRMT5) is overexpressed in many cancer
types and is a promising therapeutic target for several of them, including leukemia and …

Abstract Protein arginine methyltransferase 5 (PRMT5) complexed with MEP50/WDR77
catalyzes arginine methylation on histones and other proteins. PRMT5-MEP50 activity is …