Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral
innate immune system as they detect conserved viral pathogen-associated molecular …

As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair
not only as structural cells but also exerting important immune functions. This review focuses …

The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients …

The detection of pathogens through nucleic acid sensors is a defining principle of innate
immunity. RNA-sensing and DNA-sensing receptors sample subcellular compartments for …

Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …

DNA damage can be sensed as a danger-associated molecular pattern by the innate
immune system. Here we find that keratinocytes and other human cells mount an innate …

Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an
endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from …

The fact that a subset of human cancers showed evidence for a spontaneous adaptive
immune response as reflected by the T cell‐inflamed tumor microenvironment phenotype …