Influenza viruses are significant human respiratory pathogens that cause both seasonal,
endemic infections and periodic, unpredictable pandemics. The worst pandemic on record …

Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share
many physiological parallels, such as highly similar immune systems, with them. Importantly …

Alpha/beta interferon immune defenses are essential for resistance to viruses and can be
triggered through the actions of the cytoplasmic helicases retinoic acid-inducible gene I (RIG …

The replication and pathogenicity of influenza A virus (FLUAV) are controlled in part by the
alpha/beta interferon (IFN-α/β) system. This virus-host interplay is dependent on the …

The mechanisms responsible for the virulence of the highly pathogenic avian influenza
(HPAI) and of the 1918 pandemic influenza virus in humans remain poorly understood. To …

Influenza viruses have perplexed scientists for over a hundred years. Yearly vaccines limit
their spread, but they do not prevent all infections. Therapeutic treatments for those …

Microarray gene expression data generally suffers from missing value problem due to a
variety of experimental reasons. Since the missing data points can adversely affect …

How viral and host factors contribute to the severe pathogenicity of the H5N1 subtype of
avian influenza virus infection in humans is poorly understood. We identified three clusters …

Background One requisite of quantitative reverse transcription PCR (qRT-PCR) is to
normalise the data with an internal reference gene that is invariant regardless of treatment …

The enormous toll on human life during the 1918–1919 Spanish influenza pandemic is a
constant reminder of the potential lethality of influenza viruses. With the declaration by the …