The reactions of organic azides and alkynes catalysed by copper species represent the
prototypical examples of click chemistry. The so-called CuAAC reaction (copper-catalysed …

The copper‐catalyzed azide/alkyne cycloaddition reaction (CuAAC) has emerged as the
most useful “click” chemistry. Polymer science has profited enormously from CuAAC by its …

Sulfur (vi) fluoride exchange (SuFEx) is a category of click chemistry that enables covalent
linking of modular units through sulfur (vi) connective hubs. The efficiency of SuFEx and the …

During the past years, a variety of scientific and methodological developments have been
achieved, which urge chemists to increase the tools of their arsenal to improve the ease and …

The emergence of bioorthogonal reactions has greatly broadened the scope of biomolecule
labeling and detecting. Of all the bioorthogonal reactions that have been developed, the …

Considerable attention has been focused on improving the biocompatibility of Cu (I)-
catalyzed azide–alkyne cycloaddition (CuAAC), a hallmark of bioorthogonal reaction, in …

The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is one of the most broadly
applicable and easy-to-handle reactions in the arsenal of organic chemistry. However, the …

Protein glycosylation is a heterogeneous post-translational modification (PTM) that plays an
essential role in biological regulation. However, the diversity found in glycoproteins has …

Post-translational modifications (PTMs) on proteins often function to regulate signaling
cascades, with the activation of T cells during an adaptive immune response being a classic …

The lack of tools to observe drug-target interactions at cellular resolution in intact tissue has
been a major barrier to understanding in vivo drug actions. Here, we develop clearing …