Abstract Oestrogen receptor-positive (ER+) breast cancer is a major cause of cancer death
in women. Although aromatase inhibitors suppress the function of ER and reduce the risk of …

Purpose To develop a guideline to improve the accuracy of immunohistochemical (IHC)
estrogen receptor (ER) and progesterone receptor (PgR) testing in breast cancer and the …

Several new systemic therapy options have become available for patients with metastatic
breast cancer, which have led to improvements in survival. In addition to patient and clinical …

Importance The influence of menopausal hormone therapy on breast cancer remains
unsettled with discordant findings from observational studies and randomized clinical trials …

Breast cancer is the most prevalent cancer in women, and over two-thirds of cases express
estrogen receptor-α (ER-α, encoded by ESR1). Through a prospective clinical sequencing …

Purpose: We undertook this study to determine the prevalence of estrogen receptor (ER) α
(ESR1) mutations throughout the natural history of hormone-dependent breast cancer and to …

To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-
genome comparisons with originating breast cancers representative of the major intrinsic …

Purpose To develop recommendations about endocrine therapy for women with hormone
receptor (HR)–positive metastatic breast cancer (MBC). Methods The American Society of …

Context The Women's Health Initiative Estrogen-Alone Trial was stopped early after a mean
of 7.1 years of follow-up because of an increased risk of stroke and little likelihood of altering …

Prostate and breast cancer are the two cancers with the highest incidence in men and
women, respectively. Here, we focus on the known biology of acquired resistance to …