Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

Small-cell lung cancer (SCLC) encounters up 15% of all lung cancers, and is characterized
by a high rate of proliferation, a tendency for early metastasis and generally poor prognosis …

Metastasis has long been understood to lead to the overwhelming majority of cancer-related
deaths. However, our understanding of the metastatic process, and thus our ability to …

Lung cancer is the leading cause of cancer related death, and is divided into two major
histological subtypes, non-small cell lung cancer (NSCLC) and small cell lung cancer …

Small-cell lung cancer (SCLC) has traditionally been considered a recalcitrant cancer with a
dismal prognosis, with only modest advances in therapeutic strategies over the past several …

Small cell lung cancer (SCLC) is a rapidly growing, highly metastatic, and relatively immune-
cold lung cancer subtype. Historically viewed in the laboratory and clinic as a single …

Small cell lung cancer (SCLC) lacks effective treatments to overcome chemoresistance.
Here we established multiple human chemoresistant xenograft models through long-term …

MYCN oncogene amplification is frequently observed in aggressive childhood
neuroblastoma. Using an unbiased large-scale mutagenesis screen in neuroblastoma …

Ubiquitin-specific protease 7 (USP7) is a member of one of the most largely studied families
of deubiquitylating enzymes. It plays a key role modulating the levels of multiple proteins …

Molecular targeted therapy has revolutionized the landscape of cancer treatment due to
better therapeutic responses and less systemic toxicity. However, therapeutic resistance is a …