Rho family GTPases are critical regulators of cellular functions that play important roles in
cancer progression. Aberrant activity of Rho small G-proteins, particularly Rac1 and their …

Radiation therapy (RT) is a standard treatment for solid tumors and about 50% of patients
with cancer, including pediatric cancer, receive RT. While RT has significantly improved the …

Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem
cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor …

Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular
functions during embryonic development, both in healthy cells and in disease conditions like …

Rho GTPases, a family of the Ras GTPase superfamily, are key regulators of the actin
cytoskeleton. They were originally thought to primarily affect cell migration and invasion; …

Radiation therapy (RT) is commonly used for the treatment of localized prostate cancer
(PCa). However, cancer cells often develop resistance to radiation through unknown …

Abstract Bactericidal/permeability-increasing-fold-containing family B member 1 (BPIFB1,
previously named LPLUNC1) is highly expressed in the nasopharynx and significantly …

Aquaporin-5 (AQP5), belonging to the aquaporins (AQPs) family of transmembrane water
channels, facilitates osmotically driven water flux across biological membranes and the …

Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is
a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of …

Breast cancer (BC) is the most frequently diagnosed cancer among women in all the
populations of the world. Although the BC mortality rate has declined, resistance to treatment …