The average age of fathers at first pregnancy has risen significantly over the last decade
owing to various variables, including a longer life expectancy, more access to contraception …

Over the last decade, there has been a significant increase in average paternal age when
the first child is conceived, either due to increased life expectancy, widespread use of …

Leukocyte telomere length (LTL) is a proposed marker of biological age. Here we report the
measurement and initial characterization of LTL in 474,074 participants in UK Biobank. We …

BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …

Telomeres are the heterochromatic repeat regions at the ends of eukaryotic chromosomes,
whose length is considered to be a determinant of biological ageing. Normal ageing itself is …

Reduced fertility typically occurs among women in their late 30s, but increasing evidence
indicates that advanced paternal age is associated with changes in reproduction as well …

Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …

Telomere length (TL) has been associated with aging and mortality, but individual
differences are also influenced by genetic factors, with previous studies reporting heritability …

OBJECTIVE: To provide a systematic review of the relationship between age and leukocyte
telomere length (LTL) in adults. METHODS: Relevant studies were identified by a systematic …

Telomeres, the DNA–protein structures located at the ends of chromosomes, have been
proposed to act as a biomarker of aging. In this review, the human evidence that telomere …