Metabolic reprogramming is a hallmark of solid cancers. Macrophages as major constituents
of immune system take important roles in regulation of tumorigenesis. Pro-tumor M2 …

The interplay between extracellular matrix (ECM) stiffness and the tumor microenvironment
is increasingly recognized as a critical factor in cancer progression and the efficacy of …

Mechanistic toxicology provides a powerful approach to inform on the safety of chemicals
and the development of safe‐by‐design compounds. Although toxicogenomics supports …

Extensive infiltration of tumor-associated macrophages was correlated poor prognosis in
anaplastic thyroid cancer (ATC). However, the heterogeneity and characteristics of the ATC …

Tissue-resident myeloid cells sense and transduce mechanical signals such as stiffness,
stretch and compression. In the past two years, our understanding of the mechanosensitive …

Molecular engineering of drug delivering platforms to provide collaborative biological effects
with loaded drugs is of great medical significance. Herein, cannabinoid receptor 1 (CB1) …

Adipose tissue remodeling and plasticity are dynamically regulated by the coordinated
functions of adipocytes, macrophages, and endothelial cells and extracellular matrix (ECM) …

The extracellular matrix (ECM) is a major constituent of the tumor microenvironment, acting
as a mediator that supports the progression of gastrointestinal (GI) cancers, particularly in …

Pancreatic ductal adenocarcinoma (PDAC) is associated with a vast stromal reaction that
arises mainly from cancer-associated fibroblasts (CAFs) and promotes both immune escape …

Simple Summary Pancreatic cancer ranks as the fourth leading cause of cancer-related
death in the United States. In fact, it is estimated that there will be 64,050 new cases and …