Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

Since their first use in bioconjugation more than 50 years ago, maleimides have become
privileged chemical partners for the site-selective modification of proteins via thio-Michael …

The term “click chemistry” describes a class of organic transformations that were developed
to make chemical synthesis simpler and easier, in essence allowing chemists to combine …

Immuno-positron emission tomography (immunoPET) with 89Zr-labeled antibodies has
shown great potential in cancer imaging. It can provide important information about the …

This review describes general concepts with regard to radiopharmaceuticals for diagnostic
or therapeutic applications that help to understand the specific challenges encountered …

Analytical chemistry is now developing mainly in two areas: automation and the creation of
complexes that allow, on the one hand, for simultaneously analyzing a large number of …

Radiopharmaceuticals have proven to be effective agents, since they can be successfully
applied for both diagnostics and therapy. Effective application of relevant radionuclides in …

Antibody drug conjugates (ADCs) are promising cancer therapeutics with minimal toxicity as
compared to small cytotoxic molecules alone and have shown the evidence to overcome …

Inert and stable radiolabeling of monoclonal antibodies (mAb), antibody fragments, or
antibody mimetics with radiometals is a prerequisite for immuno-PET. While radiolabeling is …

Targeted alpha-particle therapy (TAT) aims to selectively deliver radionuclides emitting α-
particles (cytotoxic payload) to tumors by chelation to monoclonal antibodies, peptides or …