Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated
mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury …

Macroautophagy/autophagy is vital for intracellular quality control and homeostasis.
Therefore, careful regulation of autophagy is very important. In the past 10 years, a number …

Introduction Excessive inflammation and the pyroptosis of vascular endothelial cells caused
by estrogen deficiency is one cause of atherosclerosis in post-menopausal women. The …

While cancer-associated fibroblasts (CAFs) in the tumour microenvironment may play
important roles in bladder cancer (BCa) progression, their impacts on BCa chemoresistance …

Hypoxia induces protective autophagy in glioblastoma cells and new therapeutic avenues
that target this process may improve the outcome for glioblastoma patients. Recent studies …

Abstract Background Traditional Chinese medicine suggests that Radix Achyranthis
Bidentatae nourishes and protects the kidneys, the effect of which is enhanced following a …

Biological sex influences disease development and progression. The steroid hormone 17β-
oestradiol (E2), along with its receptors, is expected to play a major role in the manifestation …

Endothelial cell dysfunction and diabetic vascular complications are intrinsically linked.
Although BDNF plays a protective role in cerebral microvascular complications caused by …

Tamoxifen is commonly used to treat patients with ESR/ER-positive breast cancer, but its
therapeutic benefit is limited by the development of resistance. Recently, alterations in …