mRNA vaccines are leading a medical revolution. mRNA technologies utilize the host's own
cells as bio-factories to produce proteins that serve as antigens. This revolutionary approach …

Colorectal cancer (CRC) is a common type of gastrointestinal tract (GIT) cancer and poses
an enormous threat to human health. Current strategies for metastatic colorectal cancer …

Glioma is a primary malignant tumor in the central nervous system. In recent years, the
treatment of glioma has developed rapidly, but the overall survival of glioma patients has not …

RNA therapeutics, such as mRNA, siRNA, and CRISPR–Cas9, present exciting avenues for
treating diverse diseases. However, their potential is commonly hindered by vulnerability to …

Nanoparticle-mediated mRNA delivery has emerged as a promising therapeutic modality,
but its growth is still limited by the discovery and optimization of effective and well-tolerated …

Mesenchymal stem cells (MSCs) exhibit substantial potential for osteoarthritis (OA) therapy
through cartilage regeneration, yet the realization of optimal therapeutic outcomes is …

Abstract mRNA‐based therapeutics increasingly demonstrate significant potential in treating
various diseases, including infectious diseases, cancers, and genetic disorders. Effective …

Abstract mRNA therapeutics have significantly evolved within the life sciences, particularly in
applications such as vaccines, tumor immunotherapy, protein replacement, gene editing …

Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG
chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG …

Messenger RNA (mRNA)-based immunotherapies and protein in situ production therapies
hold great promise for addressing theoretically all the diseases characterized by aberrant …