The antioxidative function of alpha‐ketoglutarate and its applications

S Liu, L He, K Yao - BioMed research international, 2018 - Wiley Online Library
Alpha‐ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical
role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the …

Pleiotropic effects of alpha-ketoglutarate as a potential anti-ageing agent

MM Bayliak, VI Lushchak - Ageing research reviews, 2021 - Elsevier
An intermediate of tricarboxylic acid cycle alpha-ketoglutarate (AKG) is involved in
pleiotropic metabolic and regulatory pathways in the cell, including energy production …

Cryopreservation and the freeze–thaw stress response in yeast

E Cabrera, LC Welch, MR Robinson, CM Sturgeon… - Genes, 2020 - mdpi.com
The ability of yeast to survive freezing and thawing is most frequently considered in the
context of cryopreservation, a practical step in both industrial and research applications of …

Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast

A Kaya, CZJ Phua, M Lee, L Wang, A Tyshkovskiy… - Elife, 2021 - elifesciences.org
To understand the genetic basis and selective forces acting on longevity, it is useful to
examine lifespan variation among closely related species, or ecologically diverse isolates of …

Potential clinical applications of alpha‑ketoglutaric acid in diseases

X Meng, H Liu, L Peng, W He… - Molecular Medicine …, 2022 - spandidos-publications.com
As an intermediate of the tricarboxylic acid cycle, also known as 2‑oxoglutarate, α‑
ketoglutaric acid (AKG) plays an important role in maintaining physiological functions and …

Improvement of Ethanol Tolerance by Inactive Protoplast Fusion in Saccharomyces cerevisiae

Y Xin, M Yang, H Yin, J Yang - BioMed Research International, 2020 - Wiley Online Library
Saccharomyces cerevisiae is a typical fermentation yeast in beer production. Improving
ethanol tolerance of S. cerevisiae will increase fermentation efficiency, thereby reducing …

Enhancing freeze–thaw tolerance in baker's yeast: strategies and perspectives

A Chen - Food Science and Biotechnology, 2024 - Springer
Frozen dough technology is important in modern bakery operations, facilitating the
transportation of dough at low temperatures to downstream sales points. However, the …

The cardio‐and neuroprotective effects of corvitin and 2‐oxoglutarate in rats with pituitrin‐isoproterenol‐induced myocardial damage

V Tkachenko, Y Kovalchuk… - Biochemistry …, 2018 - Wiley Online Library
Heart diseases, especially acute coronary syndrome (ACS), are among the most severe
illnesses that often lead to death. Despite significant advances in the prevention and …

[HTML][HTML] Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins

S Tabibzadeh - Aging and Disease, 2022 - ncbi.nlm.nih.gov
According to the cell centric hypotheses, the deficits that drive aging occur within cells by
age dependent progressive damage to organelles, telomeres, biologic signaling pathways …

Alpha‐ketoglutarate supplementation in long‐lived Drosophila melanogaster: Impact on lifespan and metabolic responses

O Demianchuk, M Lylyk, V Balatskiy… - Archives of Insect …, 2024 - Wiley Online Library
Studies on antiaging remedies in insect models sometimes show discrepancies in results.
These discrepancies could be explained by different responses of short‐and long‐lived …