RNA viruses include many important human and animal pathogens, such as the influenza
viruses, respiratory syncytial virus, Ebola virus, measles virus and rabies virus. The …

Ebola virus (EBOV), member of genus Ebolavirus, family Filoviridae, have a non-segmented,
single-stranded RNA that contains seven genes:(a) nucleoprotein (NP),(b) viral protein 35 …

Rift Valley fever virus (RVFV) is a zoonotic pathogen with pandemic potential. RVFV entry is
mediated by the viral glycoprotein (Gn), but host entry factors remain poorly defined. Our …

Ebola virus (EBOV) infection often results in fatal illness in humans, yet little is known about
how EBOV usurps host pathways during infection. To address this, we used affinity tag …

Filoviruses, including the Ebola and Marburg viruses, cause hemorrhagic fevers with up to
90% lethality. The viral nucleocapsid is assembled by polymerization of the nucleoprotein …

Transcription of the Ebola virus genome depends on the viral transcription factor VP30 in its
unphosphorylated form, but the underlying molecular mechanism of VP30 …

Filovirus-infected cells are characterized by typical cytoplasmic inclusion bodies (IBs)
located in the perinuclear region. The formation of these IBs is induced mainly by the …

The virus life cycle depends on host-virus protein-protein interactions, which often involve a
disordered protein region binding to a folded protein domain. Here, we used proteomic …

Research on filoviruses has historically focused on the highly pathogenic ebola-and
marburgviruses. Indeed, until recently, these were the only two genera in the filovirus family …

Ebola virus nucleoprotein (eNP) assembles into higher-ordered structures that form the viral
nucleocapsid (NC) and serve as the scaffold for viral RNA synthesis. However, molecular …