Catalytic transformation of ubiquitous C–H bonds into valuable C–N bonds offers an efficient
synthetic approach to construct N-functionalized molecules. Over the last few decades …

Conspectus Asymmetric functionalization of inert C–H bonds is undoubtedly a synthetically
significant yet challenging bond-forming process, allowing for the preparation of densely …

Transition‐metal‐catalyzed C H activation has recently emerged as a powerful tool for the
functionalization of organic molecules. While many efforts have focused on the …

The Pd-catalyzed reaction of an aryl halide with an alkene affords, in most cases, the
corresponding arylalkene. It is usually considered that this reaction, which is called the Heck …

Transition metal-catalyzed C–H amination at positions adjacent to double bonds and
carbonyl groups is discussed in this critical review. While the focus will center on the recent …

An efficient method for intermolecular branch-selective allylic C–H amidation has been
accomplished via Ir (III) catalysis. The reaction proceeds through initial allylic C–H activation …

Increasing interest in C (sp3)–H bond functionalization has led to a multitude of recent
advances in intramolecular C (sp3)–H amination. Direct, intramolecular C (sp3)–N bond …

Nitrogen-containing compounds are the most common structural architectures in drug
candidates, natural and biological products, and small-molecule therapeutics. Within the …

Nitrogen heterocycles are of great medicinal importance, and the construction of nitrogen
heterocyclic scaffolds has been one of the focuses in synthetic organic chemistry. Recently …

The first catalytic allylic C–H fluorination reaction using a nucleophilic fluoride source is
reported. Under the influence of a Pd/Cr cocatalyst system, simple olefin substrates undergo …