The innovative development of azapeptide analogues of growth hormone releasing peptide-
6 (GHRP-6) has produced selective modulators of the cluster of differentiation 36 receptor …

Peptides are highly potent biological active compounds with excellent selectivity and
binding, but they have some drawbacks (eg, low stability in vivo because of the enzymatic …

Macrocyclization has enabled the use of peptides in drug discovery creating a need for
methods to synthesize diverse peptide macrocycles. Azapeptides have advanced to …

A direct cross-coupling of propiolic acid with two kinds of in situ formed iminiums has been
achieved via the CuI/CuCl2-catalyzed decarboxylative A3/A3 domino process. This novel …

For over 50 years of azapeptide synthetic techniques, developments have renewed the field
of peptidomimetic therapeutics. Azapeptides are close surrogates of natural peptides: they …

Peptidomimetics, the mimics of natural peptides are considered as promising therapeutics
with potential applications in modern medicine. Among the various structural variants of …

Azapeptides have gained much attention due to their ability to enhance the stability and
bioavailability of peptide drugs. Their structural preferences, essential to understanding their …

A microwave‐assisted copper‐catalyzed A3 cross‐coupling/decarboxylative A3 domino
reaction of a propiolic acid, an aldehyde, a formaldehyde solution and an amine is …

Aza-peptides are promising drug leads, however extensive study of their properties is
hampered by low yielding aza-peptide bond formation during conventional Fmoc SPPS. The …

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating
reagents, 4-(tosylmethyl) semicarbazones, has been developed. The synthesis involved …