Runt-related transcription factor 2 (Runx2) is a fundamental transcription factor for bone
development. In endochondral ossification, Runx2 induces chondrocyte maturation …

The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …

Cartilage is a kind of connective tissue that buffers pressure and is essential to protect joint
movement. It is difficult to self-recover once cartilage is damaged due to the lack of blood …

Runx2 is a master transcription factor for osteogenesis. The most important phenomenon
that makes this protein a master regulator for osteogenesis is its structural integrity. In …

Runx2 (runt related transcription factor 2) and Sp7 (Sp7 transcription factor 7) are crucial
transcription factors for bone development. The cotranscription factor Cbfb (core binding …

Once believed to be limited to articular cartilage, osteoarthritis is now considered to be an
organ disease of the “whole joint.” Damage to the articular surface can lead to, be caused …

Mesenchymal stem cells (MSCs) are self-renewable cells capable for multilineage
differentiation and immunomodulation. MSCs are able to differentiate into all cell types of …

Arterial medial calcification (AMC) is a hallmark of aging, diabetes, and chronic kidney
disease. Smooth muscle cell (SMC) transition to an osteogenic phenotype is a common …

From the first reported role of the transcription factor RUNX2 in osteoblast and chondrocyte
differentiation and migration to its involvement in promigratory/proinvasive behavior of …