Ribosomal RNAs are the most abundant and universal noncoding RNAs in living organisms.
In eukaryotes, three of the four ribosomal RNAs forming the 40S and 60S subunits are borne …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

Fibrillar centers (FCs) and dense fibrillar components (DFCs) are essential morphologically
distinct sub-regions of mammalian cell nucleoli for rDNA transcription and pre-rRNA …

Background A critical step in uncovering rules of RNA processing is to study the in vivo
regulatory networks of RNA binding proteins (RBPs). Crosslinking and immunoprecipitation …

Mature ribosomal RNAs (rRNAs) are produced from polycistronic precursors following
complex processing. Precursor (pre)-rRNA processing has been extensively characterized …

Cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), control the
transition between different phases of the cell cycle. CDK/cyclin activity is regulated by CDK …

During the early stages of human large ribosomal subunit (60 S) biogenesis, an ensemble of
assembly factors establishes and fine-tunes the essential RNA functional centers of pre-60 S …

Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of
ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic …

Extracellular vesicles (EVs) are a heterogeneous group of membrane‐enclosed structures
produced by prokaryotic and eukaryotic cells. EVs carry a range of biological cargoes …

Ribose methylation is one of the two most abundant modifications in human ribosomal RNA
and is believed to be important for ribosome biogenesis, mRNA selectivity and translational …