Neutrophils have always been considered as uncomplicated front-line troopers of the innate
immune system equipped with limited proinflammatory duties. Yet recently, the role of the …

Neutrophils are the first line of defense against bacteria and fungi and help combat parasites
and viruses. They are necessary for mammalian life, and their failure to recover after …

Neutrophils have traditionally been thought of as simple foot soldiers of the innate immune
system with a restricted set of pro-inflammatory functions. More recently, it has become …

In this Review we discuss data demonstrating recently recognized aspects of neutrophil
homeostasis in the steady state, granulopoiesis in'emergency'conditions and interactions of …

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on
vascular surfaces, the first adhesive step during inflammation and immune surveillance …

Rolling adhesion on vascular surfaces is the first step in recruiting circulating leukocytes,
hematopoietic progenitors, or platelets to specific organs or to sites of infection or injury …

Neutrophils (polymorphonuclear cells; PMNs) form a first line of defense against pathogens
and are therefore an important component of the innate immune response. As a result of …

Receptor-ligand bonds strengthened by tensile mechanical force are referred to as catch
bonds. This review examines experimental data and biophysical theory to analyze why …

Neutrophil recruitment is not only vital for host defense, but also relevant in pathological
inflammatory reactions, such as sepsis. Model systems have been established to examine …

Most leukocytes can roll along the walls of venules at low shear stress (1 dyn cm− 2), but
neutrophils have the ability to roll at tenfold higher shear stress in microvessels in vivo,. The …