Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Soft materials often exhibit a distinctive power-law viscoelastic response arising from broad
distribution of time-scales present in their complex internal structure. A promising tool to …

Cartilage tissue equivalents formed from hydrogels containing chondrocytes could provide a
solution for replacing damaged cartilage. Previous approaches have often utilized elastic …

Osteoarthritis is a painful joint disease characterized by progressive degeneration of the
articular cartilage as well as associated changes to the subchondral bone, synovium, and …

Mechanical properties play important roles at different scales in biology. At the level of a
single cell, the mechanical properties mediate mechanosensing and mechanotransduction …

The cytoplasm is the largest part of the cell by volume and hence its rheology sets the rate at
which cellular shape changes can occur. Recent experimental evidence suggests that …

Chondrocytes in articular cartilage are surrounded by a narrow pericellular matrix (PCM)
that is both biochemically and biomechanically distinct from the extracellular matrix (ECM) of …

Abstract Force-displacement (FZ) curves are the most commonly used Atomic Force
Microscopy (AFM) mode to measure the local, nanoscale elastic properties of soft materials …

Cells generate and sustain mechanical forces within their environment as part of their
normal physiology. They are active materials that can detect mechanical stimulation by the …

The growth of stem cells can be modulated by physical factors such as extracellular matrix
nanotopography. We hypothesize that nanotopography modulates cell behavior by …