Staphylococcus aureus is a member of the human commensal microflora that exists,
apparently benignly, at multiple sites on the host. However, as an opportunist pathogen it …

Reactive oxygen species (ROS) are attractive weapons in both antibiotic-mediated killing
and host-mediated killing. However, the involvement of ROS in antibiotic-mediated killing …

Pathogen-host competition for manganese and intricate immunostimulatory pathways
severely attenuates the efficacy of antibacterial immunotherapy against biofilm infections …

The indispensable requirement for metals in life processes has led to the evolution of
sophisticated mechanisms that allow organisms to maintain dynamic equilibria of these ions …

First row d‐block metal ions serve as vital cofactors for numerous essential enzymes and are
therefore required nutrients for all forms of life. Despite this requirement, excess free …

Bloodstream infection is a major public health concern associated with high mortality and
high healthcare costs worldwide. Bacteremia can trigger fatal sepsis whose prevention …

The divalent transition metal cation manganese is important for protein function, particularly
under conditions of iron limitation, nitrosative stress, and oxidative stress, but can mediate …

Iron is a critical nutrient for most microbial pathogens, and the immune system exploits this
requirement by sequestering iron. The opportunistic pathogen Pseudomonas aeruginosa …

Manganese serves as an indispensable catalytic center and the structural core of various
enzymes that participate in a plethora of biological processes, including oxidative …

The host protein calprotectin inhibits the growth of a variety of bacterial pathogens through
metal sequestration in a process known as “nutritional immunity.” Staphylococcus aureus …