Mitogen-activated protein kinase pathways
MJ Robinson, MH Cobb - Current opinion in cell biology, 1997 - Elsevier
Nearly all cell surface receptors utilize one or more of the mitogen-activated protein kinase
cascades in their repertoire of signal transduction mechanisms. Recent advances in the …
cascades in their repertoire of signal transduction mechanisms. Recent advances in the …
MAP kinases
Z Chen, TB Gibson, F Robinson, L Silvestro… - Chemical …, 2001 - ACS Publications
MAP Kinases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In
Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most Read Quick View Share …
Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most Read Quick View Share …
[HTML][HTML] MAP kinase pathways
MH Cobb - Progress in biophysics and molecular biology, 1999 - Elsevier
MAP kinases help to mediate diverse processes ranging from transcription of
protooncogenes to programmed cell death. More than a dozen mammalian MAP kinase …
protooncogenes to programmed cell death. More than a dozen mammalian MAP kinase …
AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic β cells, and may regulate insulin release
IP Salt, G Johnson, SJH Ashcroft… - Biochemical …, 1998 - portlandpress.com
The role of the AMP-activated protein kinase (AMPK) cascade in the glucose-sensitive
pancreatic β cell lines HIT-T15 and INS-1 was addressed. In both cell types, removal of …
pancreatic β cell lines HIT-T15 and INS-1 was addressed. In both cell types, removal of …
High-glucose stimulation increases reactive oxygen species production through the calcium and mitogen-activated protein kinase-mediated activation of mitochondrial …
Increased production of reactive oxygen species (ROS) from mitochondria is the main cause
of hyperglycemic complications. We previously showed that hyperglycemic conditions …
of hyperglycemic complications. We previously showed that hyperglycemic conditions …
Quercetin potentiates insulin secretion and protects INS‐1 pancreatic β‐cells against oxidative damage via the ERK1/2 pathway
BACKGROUND AND PURPOSE Quercetin lowers plasma glucose, normalizes glucose
tolerance tests and preserves pancreatic β‐cell integrity in diabetic rats. However, its …
tolerance tests and preserves pancreatic β‐cell integrity in diabetic rats. However, its …
Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
Q Wang, P Brubaker - Diabetologia, 2002 - Springer
Aims/hypothesis. Glucagon-like peptide-1 ameliorates the symptoms of diabetes through
stimulation of insulin secretion and enhancement of beta-cell mass. We have therefore …
stimulation of insulin secretion and enhancement of beta-cell mass. We have therefore …
New insights into the control of MAP kinase pathways
J English, G Pearson, J Wilsbacher, J Swantek… - Experimental cell …, 1999 - Elsevier
Mitogen-activated protein (MAP) kinases, found in all eukaryotes, are common participants
in signal transduction pathways from the membrane to the nucleus [1–3]. They signal in a …
in signal transduction pathways from the membrane to the nucleus [1–3]. They signal in a …
Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic β-cell line INS-1
SP Cousin, SR Hugl, CE Wrede, H Kajio… - …, 2001 - academic.oup.com
Pancreatic β-cell mitogenesis is increased by insulin-like growth factor I (IGF-I) in a glucose-
dependent manner. In this study it was found that alternative β-cell nutrient fuels to glucose …
dependent manner. In this study it was found that alternative β-cell nutrient fuels to glucose …
Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A-and a …
H Hui, A Nourparvar, X Zhao, R Perfetti - Endocrinology, 2003 - academic.oup.com
The activation of the glucagon-like peptide-1 (GLP-1) receptor has been shown to have an
important role in the functional activity of islet β-cells and in the expansion of the islet cell …
important role in the functional activity of islet β-cells and in the expansion of the islet cell …